Wayne Rooney could face his former side Manchester United in the fifth round of the FA Cup if Derby can beat Northampton in their fourth-round replay.
Chelsea will host Shrewsbury or Liverpool, while Bournemouth can set up a south coast derby with Portsmouth if they beat Arsenal in Monday’s game.
All eight ties will be played across three midweek nights from 3-5 March.
FA Cup fifth-round draw
Sheffield Wednesday v Manchester City
Reading/Cardiff City v Sheffield United
Chelsea v Shrewsbury Town/Liverpool
West Bromwich Albion v Newcastle United or Oxford United
Leicester City v Coventry City or Birmingham City
Northampton Town/Derby County v Manchester United
Southampton/Tottenham Hotspur v Norwich City
Portsmouth v Bournemouth/Arsenal